Abstract: Sequential decision-making under cost-sensitive tasks is prohibitively daunting, especially for the problem that has a significant impact on people's daily lives, such as malaria control, treatment recommendation. The main challenge faced by policymakers is to learn a policy from scratch by interacting with a complex environment in a few trials. This work introduces a practical, data-efficient policy learning method, named Variance-Bonus Monte Carlo Tree Search~(VB-MCTS), which can copy with very little data and facilitate learning from scratch in only a few trials. Specifically, the solution is a model-based reinforcement learning method. To avoid model bias, we apply Gaussian Process~(GP) regression to estimate the transitions explicitly. With the GP world model, we propose a variance-bonus reward to measure the uncertainty about the world. Adding the reward to the planning with MCTS can result in more efficient and effective exploration. Furthermore, the derived polynomial sample complexity indicates that VB-MCTS is sample efficient. Finally, outstanding performance on a competitive world-level RL competition and extensive experimental results verify its advantage over the state-of-the-art on the challenging malaria control task.