Abstract: Biomedical question-answering (QA) has gained increased attention for its capability to provide users with high-quality information from a vast scientific literature. Although an increasing number of biomedical QA datasets has been recently made available, those resources are still rather limited and expensive to produce; thus, transfer learning via pre-trained language models (LMs) has been shown as a promising approach to leverage existing general-purpose knowledge. However, fine-tuning these large models can be costly and time consuming and often yields limited benefits when adapting to specific themes of specialised domains, such as the COVID-19 literature. Therefore, to bootstrap further their domain adaptation, we propose a simple yet unexplored approach, which we call biomedical entity-aware masking (BEM) strategy, encouraging masked language models to learn entity-centric knowledge based on the pivotal entities characterizing the domain at hand, and employ those entities to drive the LM fine-tuning. The resulting strategy is a downstream process applicable to a wide variety of masked LMs, not requiring additional memory or components in the neural architectures. Experimental results show performance on par with the state-of-the-art models on several biomedical QA datasets.